HRID1992471

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5151595

2-Chloro-4-pyridylboronic acid

C5H5BClNO2

结构：CC(C)N1CCN(C(=O)c2ccc3[nH]c(C(=O)N4CCN(C(=O)N5CCCCC5)CC4)cc3c2)CC1

HCID68533742

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCN(C(=O)c2ccc3c(c2)cc(C(=O)N2CCN(C(=O)N4CCCCC4)CC2)n3-c2ccnc(Cl)c2)CC1

HCID24986210

未命名化合物

收率 62%

PROCEDURE

实验过程

The title compound was synthesized in analogy to example 5, after stirring for 3.5 days at 35° C., from {4-[5-(4-isopropyl-piperazine-1-carbonyl)-1H-indole-2-carbonyl]-piperazin-1-yl}-piperidin-1-yl-methanone (example 14) and 2-chloropyridine-4-boronic acid to afford the desired product as a light-brown foam (62%). MS (ISP): 606.1 (M+H)+.

WORKUP

后处理

customThe title compound was synthesized in analogy to example 5

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4820eaf14d8b43b087b7f4daa3d37d5c
来源数据集: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07648979B2
来源说明: uspto-grants-2010_01

反应 SMILES

[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[CH:13]=[C:14]3[C:18](=[CH:19][CH:20]=2)[NH:17][C:16]([C:21]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([N:31]4[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]4)=[O:30])[CH2:25][CH2:24]2)=[O:22])=[CH:15]3)=[O:11])[CH2:6][CH2:5]1)([CH3:3])[CH3:2].[Cl:37][C:38]1[CH:43]=[C:42](B(O)O)[CH:41]=[CH:40][N:39]=1>>[Cl:37][C:38]1[CH:43]=[C:42]([N:17]2[C:18]3[C:14](=[CH:13][C:12]([C:10]([N:7]4[CH2:6][CH2:5][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:9][CH2:8]4)=[O:11])=[CH:20][CH:19]=3)[CH:15]=[C:16]2[C:21]([N:23]2[CH2:24][CH2:25][N:26]([C:29]([N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)=[O:30])[CH2:27][CH2:28]2)=[O:22])[CH:41]=[CH:40][N:39]=1