Methylamine → [6-(4-Amino-benzyl)-pyrimidin-4-yl]-methyl-amine

HRID 1993557Notes

Reaction equation

[CH3:1][NH2:2].Cl[C:4]1[N:9]=[CH:8][N:7]=[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][CH:12]=2)[CH:5]=1>CCO>[NH2:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][C:6]2[N:7]=[CH:8][N:9]=[C:4]([NH:2][CH3:1])[CH:5]=2)=[CH:12][CH:13]=1

Participants

Conditions

Temperature: 50 °C

Procedure

A 4 N solution of HCl in dioxane (11.7 mL, 46.9 mmol, 30 equiv) is added to a solution of [4-(6-chloro-pyrimidin-4-ylmethyl)-phenyl]-carbamic acid tert-butyl ester (Example 117) (0.50 g, 1.56 mmol) in CH2Cl2 (6.7 mL), under an argon atmosphere. The resulting white suspension is stirred at rt for 6.5 h. Additional 4 N HCl solution (1.1 mL, 4.6 mmol, 3.0 equiv) is added. The reaction mixture is allowed to stir for 0.5 h and concentrated in vacuo to afford 0.467 g of crude 4-(6-chloro-pyrimidin-4-ylmethyl)-phenylamine as a white solid. An 8 M solution of methylamine in EtOH (5.1 mL, 40.0 mmol, 30 equiv) Is added to a solution of crude 4-(6-chloro-pyrimidin-4-ylmethyl)phenylamine (0.300 g, 1.37 mmol) in EtOH (2.7 mL), under an argon atmosphere. The mixture Is heated to 50° C. (oil bath temperature) for 5 h, allowed to cool to rt and concentrated in vacuo. The residue is purified by silica gel (48 g) column chromatography (CH2Cl2/MeOH, 85/15) to afford the title compound as a light yellow oil: ES-MS: 215.0 [M+H]+; single peak at tR=3.03 min (System 2); Rf=0.49 (CH2Cl2/MeOH, 85/15).

Workup

temperatureto cool to rt
concentrationconcentrated in vacuo
customThe residue is purified by silica gel (48 g) column chromatography (CH2Cl2/MeOH, 85/15)

Sources & evidence

ORD record: ord-0e48710694d94f8d8fc8532603c43b16
Source dataset: uspto-grants-2010_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07652022B2

Reaction notes

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