反应详情

To the title B compound, (R)-1-[3-(t-butyl-dimethyl-silanyloxy)-phenylsulfanyl-carbonyl]-pyrrolidine-2-carboxylic acid ethyl ester (1.5 g, 3.66 mmol) in a flask at RT, is added 1 M solution of n-tetrabutylammonium fluoride (14.6 mL, 14.6 mmol) in THF and the reaction is stirred for 4 h. The reaction mixture is concentrated at reduced pressure, diluted with ethyl acetate, washed with water and brine, dried over anhydrous magnesium sulfate and concentrated. The crude (R)-1-(3-hydroxy-phenylsulfanylcarbonyl)-pyrrolidine-2-carboxylic acid ethyl ester is used in the next step without further purification.

1. concentrationThe reaction mixture is concentrated at reduced pressure
2. additiondiluted with ethyl acetate
3. washwashed with water and brine
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationconcentrated
6. customThe crude (R)-1-(3-hydroxy-phenylsulfanylcarbonyl)-pyrrolidine-2-carboxylic acid ethyl ester is used in the next step without further purification