反应详情

Intermediate 14 was coupled with the product of Example 27, step B following the procedure of Example 27, step C. The crude product was purified by flash column chromatography (8:2 hexanes/ethyl acetate) to give tert-butyl 2-(4-methoxyphenyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (106 mg, 34%) as a light-yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.17 (s, 1H), 7.88 (d, J=8.7 Hz, 2H), 7.60-7.71 (m, 1H), 7.27-7.32 (m, 1H), 6.92 (d, J=9.0 Hz, 2H), 5.26 (br s, 1H), 4.69 (br s, 1H), 3.82 (s, 3H), 3.59 (s, 3H), 3.40 (br s, 1H), 2.49 (d, J=16.2 Hz, 1H), 2.12-2.39 (m, 2H), 1.88-2.01 (m, 1H), 1.53-1.72 (m, 1H), 1.38 (br s, 9H).

1. customThe crude product was purified by flash column chromatography (8:2 hexanes/ethyl acetate)