反应详情

Intermediate 23 was coupled with the product of Example 27, step B following the procedure of Example 27, Step C. The crude product was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate) to give tert-butyl 2-(1-napthyl)sulfonyl-5-methyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (120 mg, 26%) as a light yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.48 (dd, J=7.5, 1.2 Hz, 1H), 8.20 (s, 1H), 8.04 (d, J=8.4 Hz, 1H), 7.86 (dd, J=8.6, 1.5 Hz, 1H), 7.67 (d, J=8.7 Hz, 1H), 7.59 (t, J=7.8 Hz, 1H), 7.40-7.52 (m, 4H), 5.25 (br s, 1H), 4.69 (br s, 1H), 3.59 (s, 3H), 3.36 (br s, 1H), 2.45 (d, J=6.0 Hz, 1H), 2.14-2.38 (m, 2H), 1.87-1.96 (m, 1H), 1.59-1.67 (m, 1H), 1.37 (br s, 9H).

1. customThe crude product was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate)