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HRID2036736

反应详情

EQUATION

反应方程式

HRID 2036736 的结构方程式

REACTANTS

反应物

2
结构：O=[N+]([O-])c1ccc(S(=O)[O-])cc1.[Na+]
HCID12249756

未命名化合物

结构：Cc1cc(Br)c(C(=O)OC(C)(C)C)c2c3c(n(C)c12)CC1CCC3N1
HCID67085249

Tert-butyl 2-bromo-4,5-dimethyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate

C20H25BrN2O2

PRODUCTS

生成物

1
结构：Cc1cc(S(=O)(=O)c2ccc([N+](=O)[O-])cc2)c(C(=O)OC(C)(C)C)c2c3c(n(C)c12)CC1CCC3N1
HCID67085768

未命名化合物

收率 6%

PROCEDURE

实验过程

Intermediate 12 was coupled to the product of Example 71, step C following the procedure of Example 71, step D. The crude product was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate) to give tert-butyl 2-(4-nitro-phenyl)sulfonyl-4,5-dimethyl-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole-carboxylate (44 mg, 6%) as a yellow solid: 1H NMR (CDCl3, 300 MHz) δ 8.86-8.33 (m, 2H), 8.08-8.16 (m, 2H), 8.03 (s, 1H), 7.34 (s, 1H), 5.23 (br s, 1H), 4.71 (br s, 1H), 3.85 (s, 3H), 3.36 (br s, 1H), 2.76 (s, 3H), 2.46 (d, J=16.2 Hz, 1H), 2.11-2.39 (m, 2H), 1.85-1.97 (m, 1H), 1.53-1.67 (m, 1H), 1.36 (br s, 9H).

WORKUP

后处理

  1. customThe crude product was purified by flash column chromatography (SiO2, 8:2 hexanes/ethyl acetate)