反应详情

To a solution tert-butyl 4-(2-carbamoylbiphenyl-3-ylcarbamoyl)piperidine-1-carboxylate (1.0 g, 2.4 mmol) in methanol was added NaOMe (2.6 mL, 25% in MeOH, 12.3 mmol). The resulting reaction mixture was stirred at RT for 14 h. After this time, the reaction mixture was concentrated under reduced pressure and the resulting residue was diluted with ethyl acetate and then washed with water. The organic portion was dried, concentrated under reduced pressure to yield a residue. The residue was purified by ISCO chromatography (30% EtOAc in hexanes) to yield tert-butyl 4-(4-oxo-5-phenyl-3,4-dihydroquinazolin-2-yl)piperidine-1-carboxylate (0.60 g, 67% yield) as a white solid. LCMS Method W: retention time 2.07 min; [M+1]=422.2.

1. customThe resulting reaction mixture
2. concentrationAfter this time, the reaction mixture was concentrated under reduced pressure
3. additionthe resulting residue was diluted with ethyl acetate
4. washwashed with water
5. customThe organic portion was dried
6. concentrationconcentrated under reduced pressure
7. customto yield a residue
8. customThe residue was purified by ISCO chromatography (30% EtOAc in hexanes)