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HRID2038563

反应详情

EQUATION

反应方程式

HRID 2038563 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)[C@H](NC(=O)OC1CCCC1)C(=O)O
HCID23595129

N-[(Cyclopentyloxy)carbonyl]-3-methyl-L-valine

C12H21NO4

结构：COC(=O)[C@@H]1C[C@]2(CN1)CN(c1cccc(Cl)c1)C(=O)O2
HCID59547337

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1C[C@@]2(CN(c3cccc(Cl)c3)C(=O)O2)CN1C(=O)[C@@H](NC(=O)OC1CCCC1)C(C)(C)C
HCID59547346

未命名化合物

收率 42.3%

PROCEDURE

实验过程

Following the same procedure as Example 1 step G using (5S,8S)-methyl-3-(3-chlorophenyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (30 mg, 97 μmol) and (S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoic acid (28 mg, 116 μmol, 1.2 eq.) gave 22 mg (41 μmol) of (5S,8S)-methyl-3-(3-chlorophenyl)-7-((S)-2-(cyclopentyloxycarbonylamino)-3,3-dimethylbutanoyl)-2-oxo-1-oxa-3,7-diazaspiro[4.4]nonane-8-carboxylate (C3). 1H NMR (300 MHz, CDCl3) 7.35-6.8 (m, 4H), 5.21-5.06 (m, 1H), 4.86 (m, 1H), 4.55-3.56 (m, 8H), 2.65-2.48 (m, 1H), 2.0 (m, 1H), 1.7-1.1 (m, 9H), 0.9-0.7 (m, 9H).