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HRID2040850

反应详情

EQUATION

反应方程式

HRID 2040850 的结构方程式

REACTANTS

反应物

4
反应SMILES：Clc1cccc(I)c1
HCID12269

Benzene, 1-chloro-3-iodo-

C6H4ClI

反应SMILES：C=C1CCN(C(=O)OC(C)(C)C)CC1
HCID2756808

tert-Butyl 4-methylidenepiperidine-1-carboxylate

C11H19NO2

反应SMILES：C=C1CCN(c2ncccc2[N+](=O)[O-])CC1
HCID57493809

未命名化合物

反应SMILES：C=C1CCN(c2nc(C)ccc2[N+](=O)[O-])CC1
HCID57493810

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)(C)OC(=O)N1CCC2(CC1)CC(C#Cc1cccc(Cl)c1)=NO2
HCID57493815

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized following the method reported for the compound of Example 3, substituting 2-bromo-6-methylpyridine with 1-chloro-3-iodobenzene and Compound 3c with Compound 2a, with tert-butyl 4-methylenepiperidine-1-carboxylate. After the usual work-up, the crude was purified by automated flash chromatography (SP1®TM -Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 6:4) affording the title product as white solid. Yield: 76.9%.

WORKUP

后处理

  1. customThe title compound was synthesized
  2. customAfter the usual work-up, the crude was purified by automated flash chromatography (SP1®TM -Biotage; gradient Petroleum Ether-EtOAc from 95:5 to 6:4)