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HRID2040901

反应详情

EQUATION

反应方程式

HRID 2040901 的结构方程式

REACTANTS

反应物

3
结构：O=C(Cl)N1CCNC1=O
HCID83241

2-Oxoimidazolidine-1-carbonyl chloride

C4H5ClN2O2

结构：CN1CCN(C(=O)Cl)CC1
HCID3016935

4-methylpiperazine-1-carbonyl Chloride

C6H11ClN2O

结构：CN1CCN(C(=O)N2CCC3(CC(C#Cc4cccc(Cl)c4)=NO3)C2)CC1
HCID56644861

未命名化合物

PRODUCTS

生成物

1
结构：O=C1NCCN1C(=O)N1CCC2(CC(C#Cc3cccc(Cl)c3)=NO2)C1
HCID57493782

未命名化合物

收率 51.3%

PROCEDURE

实验过程

The title compound was synthesized using the method described for the compound of Example 104, replacing 1-chlorocarbonyl-2-imidazolidinone for by 4-methyl-1-piperazinecarbonyl chloride. After evaporation, the crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient EtOAc-MeOH from 95:5 to 8:2) to afford a yellowish solid. Yield: 51.3%.

WORKUP

后处理

  1. customAfter evaporation
  2. customthe crude was purified by means of automated flash chromatography (SP01®TM-Biotage; gradient EtOAc-MeOH from 95:5 to 8:2)
  3. customto afford a yellowish solid