反应详情

The title compound was prepared from methyl 3-(4-((3-hydroxyphenyl)ethynyl)phenyl)propanoate (100 mg, 0.45 mmol) and 3-bromoprop-1-yne (129 mg, 0.93 mmol) according to the general procedure IV to give 105 mg (72%) of a pure light brown oily product. Rf=0.56 (EtOAc:PE, 1:1); 1H NMR (CDCl3): δ 7.46 (dt, J=6.3 Hz, 1.8 Hz, 2H), 7.28-7.25 (m, 1H), 7.19, 7.15 (m, 3H), 7.12 (dd, J=2.5 Hz, 1.3 Hz, 1H), 6.96 (ddd, J=8.3 Hz, 2.8 Hz, 1.0 Hz, 1H), 4.70 (d, J=2.5 Hz, 2H), 3.67 (s, 3H), 2.96 (t, J=7.7 Hz, 2H), 2.64 (t, J=7.8 Hz, 2H), 2.54 (t, J=2.4 Hz, 1H); 13C NMR (CDCl3): δ 173.1, 157.3, 141.0, 131.8, 129.4, 128.3, 125.0, 124.4, 121.0, 117.4, 115.6, 89.3, 88.8, 78.3, 75.7, 55.9, 51.6, 35.4, 30.8; MALDI-MS m/z 341.4 (M+Na+).