反应详情

To a solution of (E)-ethyl 3-(4-(4-chloro-2-methoxyphenyl)-3-(4-hydroxyphenyl)thiophen-2-yl)acrylate (280 mg, 0.61 mmol) in EtOH (5 mL) was added Pd/C (50 mg). After the mixture was stirred at room temperature under H2 atmosphere for 4 hours, the mixture was filtered and concentrated in vacuo to give ethyl 3-(4-(4-chloro-2-methoxyphenyl)-3-(4-hydroxyphenyl)thiophen-2-yl)propanoate (Scheme II, 11, X1=4-hydroxyphenyl, X2=4-chloro-2-methoxyphenyl) (220 mg, yield 78%). 1H NMR (DMSO-d6 400 MHz): δ 9.34 (s, 1H), 7.26 (s, 1H), 7.01 (d, J=8.4 Hz, 1H), 6.90 (d, J=8.8 Hz, 2H), 6.79 (d, J=8.0 Hz, 2H), 6.64 (d, J=8.4 Hz, 2H), 4.04 (q, J=7.2 Hz, 2H), 3.40 (s, 3H), 2.96 (t, J=7.6 Hz, 2H), 2.55 (t, J=7.6 Hz, 2H), 1.16 (t, J=7.2 Hz, 3H).

1. filtrationthe mixture was filtered
2. concentrationconcentrated in vacuo