2,6-Dibromopyridine → HCID 86670203, compound

HRID 2046202Notes

Reaction equation

HRID 2046202 reaction equation
[O:1]([CH2:8][C:9]1[CH:18]=[C:12]2[C:13](=[O:17])[NH:14][CH2:15][CH2:16][N:11]2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22](Br)[N:21]=1.FC1C=C(F)C=CC=1N1CCN2N=C(COC3C=CC=CC=3)C=C2C1=O>>[Br:19][C:20]1[N:21]=[C:22]([N:14]2[CH2:15][CH2:16][N:11]3[N:10]=[C:9]([CH2:8][O:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:18]=[C:12]3[C:13]2=[O:17])[CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 122742,6-DibromopyridineHCID 57411799HCID 57411799, compoundHCID 57411802HCID 57411802, compound

Product 1

HCID 86670203HCID 86670203, compound

Procedure

The compound was prepared from 2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one and 2,6-dibromopyridine using the method described in the preceding example 43 (5-(2,4-difluoro-phenyl)-2-phenoxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one). 1H NMR (500 MHz, CDCl3) δ ppm 4.48-4.55 (m, 2H), 4.58-4.63 (m, 2H), 5.13 (s, 2H), 6.98 (t, J=7.4 Hz, 1H), 7.01 (d, J=7.8 Hz, 2H), 7.08 (s, 1H), 7.28-7.34 (m, 3H), 7.60 (t, J=7.9 Hz, 1H), 8.09 (d, J=8.1 Hz, 1H).

Sources & evidence

ORD record
ord-0e820763aee949e0ad9b2e11bb48b702
Source dataset
uspto-grants-2013_11
Patent number
US08592422B2

Reaction notes

Loading…