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HRID2047107

反应详情

EQUATION

反应方程式

HRID 2047107 的结构方程式

REACTANTS

反应物

3
结构：Nc1c(Br)c(C2CCN(CC(=O)O)CC2)nc2c(-c3cnc4ccccc4c3)cnn12
HCID58173549

未命名化合物

结构：C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1cc(C2CCC(CC#N)C2)nc2c(-c3cnc4ccccc4c3)cnn12
HCID66733406

未命名化合物

结构：CC(C)(C)OC(=O)CN1CCC(c2cc(N)n3ncc(-c4cnc5ccccc5c4)c3n2)CC1
HCID66738335

未命名化合物

PRODUCTS

生成物

1
结构：N#CCC1CCC(c2nc3c(-c4cnc5ccccc5c4)cnn3c(N)c2Br)C1
HCID58173479

未命名化合物

PROCEDURE

实验过程

2-(3-(7-amino-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclopentyl)acetonitrile was synthesized in a manner similar to the synthesis of 2-(4-(7-amino-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-1-yl)acetic acid, but with 2-(3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclopentyl)acetonitrile substituted for tert-butyl 2-(4-(7-amino-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)piperidin-1-yl)acetate. The reaction was concentrated in vacuo and purified via reverse-phase preparatory HPLC to yield 2-(3-(7-amino-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)cyclopentyl)acetonitrile as a yellow solid. (m+H=447.22, retention time=3.99 min).

WORKUP

后处理

  1. concentrationThe reaction was concentrated in vacuo
  2. custompurified via reverse-phase preparatory HPLC