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HRID2047202

反应详情

EQUATION

反应方程式

HRID 2047202 的结构方程式

REACTANTS

反应物

3
结构：Nc1c(Br)c(C2=CCNCC2)nc2c(-c3cnc4ccccc4c3)cnn12
HCID66733403

未命名化合物

结构：CC(C)(C)OC(=O)N1CC=C(c2cc(N(COCC[Si](C)(C)C)COCC[Si](C)(C)C)n3ncc(-c4cnc5ccccc5c4)c3n2)CC1
HCID67494206

未命名化合物

结构：C[Si](C)(C)CCOCN(COCC[Si](C)(C)C)c1c(Br)c(C2=CCC(c3cnn(COCC[Si](C)(C)C)c3)CC2)nc2c(-c3cnc4ccccc4c3)cnn12
HCID67494642

未命名化合物

PRODUCTS

生成物

1
结构：Nc1c(Br)c(C2=CCC(c3cn[nH]c3)CC2)nc2c(-c3cnc4ccccc4c3)cnn12
HCID58173338

未命名化合物

PROCEDURE

实验过程

5-(4-(1H-pyrazol-4-yl)cyclohex-1-enyl)-6-bromo-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine was synthesized in a manner similar to the synthesis of 6-bromo-3-(quinolin-3-yl)-5-(1,2,3,6-tetrahydropyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine, but with 6-bromo-3-(quinolin-3-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)-5-(4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-yl)cyclohex-1-enyl)pyrazolo[1,5-a]pyrimidin-7-amine substituted for tert-Butyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate. The reaction mixture was purified via reverse-phase preparatory HPLC to yield 5-(4-(1′-1-pyrazol-4-yl)cyclohex-1-enyl)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine as yellow solid. (M+H=486.12, retention time=3.43 min.

WORKUP

后处理

  1. customThe reaction mixture was purified via reverse-phase preparatory HPLC