反应详情

From 3.9 parts of N-(1-cyclopentyl-4-piperidinyl)-3-methyl-N-(3-pyridinyl)benzeneacetamide (E)-2-butenedioate, the free base is liberated in the conventional manner with a diluted sodium hydroxide solution. After extraction with 2,2'-oxybispropane, the latter is washed with water, dried, filtered and evaporated. The residue is converted into the ethanedioate salt in ethanol. The salt is filtered off and crystallized from a mixture of ethanol and 2,2'-oxybispropane, yielding 3 parts of N-(1-cyclopentyl-4-piperidinyl)-3-methyl-N-(3-pyridinyl)benzeneacetamide ethanedioate; mp. 192.6° C.

1. extractionAfter extraction with 2,2'-oxybispropane
2. washthe latter is washed with water
3. customdried
4. filtrationfiltered
5. customevaporated
6. filtrationThe salt is filtered off
7. customcrystallized from a mixture of ethanol and 2,2'-oxybispropane