反应详情

温度

40 °C

0.1 g (0.257 mmol) of N-{(1S)-1-(5-chloro-1H-benzimidazol-2-yl)-3-[3-(2-chloroethyl)ureido]propyl}-3-methyl-4-(pyrrolidin-1-ylcarbonyl)benzamide is dissolved in 5 mL of dimethylformamide and, after the addition of 50 mg (0.45 mmol) of potassium tert-butoxide, stirred for 5 hours at 40° C. Then the mixture is poured onto ice water and extracted with dichloromethane. The combined organic extracts are dried over sodium sulfate and concentrated by evaporation. The crude product is triturated with diethyl ether and suction filtered. Yield: 61%; Rf value: 0.70 (silica gel; dichloromethane/ethanol=4:1); C26H29ClN6O3 (509.01); mass spectrum: (M+H)+=509/511 (chlorine isotope) and (M−H)−=507/509 (chlorine isotope).

1. additionThen the mixture is poured onto ice water
2. extractionextracted with dichloromethane
3. dry with materialThe combined organic extracts are dried over sodium sulfate
4. concentrationconcentrated by evaporation
5. customThe crude product is triturated with diethyl ether and suction
6. filtrationfiltered