HRID2055455

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc2c(c1)c(C(=O)O)c(C)n2CCc1ccc(OC)c(OC)c1

HCID1082708

未命名化合物

HCID9834255

3H-spiro[isobenzofuran-1,4'-piperidin]-3-one

C12H13NO2

PRODUCTS

生成物

结构：COc1ccc2c(c1)c(C(=O)N1CCC3(CC1)OC(=O)c1ccccc13)c(C)n2CCc1ccc(OC)c(OC)c1

HCID59657585

未命名化合物

PROCEDURE

实验过程

Following the general procedure I as described above, the acylation of 3H-spiro[2-benzofuran-1,4′-piperidin]-3-one prepared as described in example 16 above, with commercially available 1-[2-(3,4-dimethoxy-phenyl)-ethyl]-5-methoxy-2-methyl-1H-indole-3-carboxylic acid, gave the title compound. ES-MS m/e (%): 555.3 (M+H+).

WORKUP

后处理

customprepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8663f155d2384bb2a3672d735a97f4e9
来源数据集: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07332501B2
来源说明: uspto-grants-2008_02

反应 SMILES

[NH:1]1[CH2:6][CH2:5][C:4]2([C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[O:7]2)[CH2:3][CH2:2]1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH2:26][CH2:27][N:28]2[C:36]3[C:31](=[CH:32][C:33]([O:37][CH3:38])=[CH:34][CH:35]=3)[C:30]([C:39](O)=[O:40])=[C:29]2[CH3:42])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]>>[CH3:16][O:17][C:18]1[CH:19]=[C:20]([CH2:26][CH2:27][N:28]2[C:36]3[C:31](=[CH:32][C:33]([O:37][CH3:38])=[CH:34][CH:35]=3)[C:30]([C:39]([N:1]3[CH2:6][CH2:5][C:4]4([C:10]5[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=5[C:8](=[O:15])[O:7]4)[CH2:3][CH2:2]3)=[O:40])=[C:29]2[CH3:42])[CH:21]=[CH:22][C:23]=1[O:24][CH3:25]