4,4,4-Trifluoro-but-2-enoic acid → HCID 67012040, compound

HRID 2056515Notes

Reaction equation

HRID 2056515 reaction equation
[F:1][C:2]([F:9])([F:8])[CH:3]=[CH:4][C:5](O)=[O:6].[CH:10]1([CH2:13][CH2:14][NH:15][C:16]([C:18]2[N:19]=[N:20][C:21]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[CH:22][CH:23]=2)=[O:17])[CH2:12][CH2:11]1>>[CH:10]1([CH2:13][CH2:14][NH:15][C:16]([C:18]2[N:19]=[N:20][C:21]([N:24]3[CH2:29][CH2:28][N:27]([C:5](=[O:6])[CH:4]=[CH:3][C:2]([F:9])([F:8])[F:1])[CH2:26][CH2:25]3)=[CH:22][CH:23]=2)=[O:17])[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 27824314,4,4-Trifluoro-but-2-enoic acidHCID 66849327N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide

Product 1

HCID 67012040HCID 67012040, compound

Procedure

Following the procedure of Example 9, making variations only as required to use 4,4,4-trifluorobut-2-enoic acid in place of 2,5-dichlorobenzoic acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a white powder (19.6% yield). 1H NMR (500 MHz, CDCl3) δ 8.09, 8.00, 7.00, 6.81, 3.96-3.88, 3.78, 3.57, 1.53, 0.76, 0.48, 0.10. MS (ES+) m/z 398 (M+1).

Sources & evidence

ORD record
ord-d26b3bc99caa4c7aa8b20c23090edc70
Source dataset
uspto-grants-2008_02
Patent number
US07335658B2

Reaction notes

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