Monomethyl phthalate → HCID 11166493, compound

HRID 2056549Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5](=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:6]([OH:8])=O.[CH:14]1([CH2:17][CH2:18][NH:19][C:20]([C:22]2[N:23]=[N:24][C:25]([N:28]3[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]3)=[CH:26][CH:27]=2)=[O:21])[CH2:16][CH2:15]1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([N:31]1[CH2:32][CH2:33][N:28]([C:25]2[N:24]=[N:23][C:22]([C:20](=[O:21])[NH:19][CH2:18][CH2:17][CH:14]3[CH2:16][CH2:15]3)=[CH:27][CH:26]=2)[CH2:29][CH2:30]1)=[O:8]

Participants

Reactant 2

HCID 20392Monomethyl phthalate

HCID 66849327N-(2-cyclopropylethyl)-6-(1-piperazinyl)-3-pyridazinecarboxamide

Product 1

HCID 11166493HCID 11166493, compound

Procedure

Following the procedure of Example 14, making variations only as required to use phthalic acid monomethyl ester in place of 4,4,4-trifluoro-2-methylbutyric acid to react with 6-piperazin-1-yl-pyridazine-3-carboxylic acid (2-cyclopropylethyl)amide, the title compound was obtained as a light yellow solid (97% yield). 1H NMR (300 MHz, CDCl3) δ 8.02-8.06, 7.96, 7.88, 7.60, 7.48, 7.30, 6.98, 3.72-4.02, 3.54, 3.33, 1.49, 0.74, 0.45, 0.08. MS (ES+) m/z 438 (M+1).

Sources & evidence

ORD record: ord-7fa8b04670674f3fbf0e2ab99b812f70
Source dataset: uspto-grants-2008_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07335658B2

Reaction notes

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