1-[2-(Trifluoromethyl)benzoyl]piperazine → HCID 16035661, Verbindung

HRID 2056554Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2056554
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][C:12]([C:14]2[N:15]=[N:16][C:17](Cl)=[CH:18][CH:19]=2)=[O:13])=[CH:5][CH:4]=1.[N:21]1([C:27]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=2[C:35]([F:38])([F:37])[F:36])=[O:28])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:11][C:12]([C:14]2[N:15]=[N:16][C:17]([N:24]3[CH2:25][CH2:26][N:21]([C:27](=[O:28])[C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[C:35]([F:38])([F:36])[F:37])[CH2:22][CH2:23]3)=[CH:18][CH:19]=2)=[O:13])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazineHCID 608591896-Chloro-N-[2-(4-methoxyphenyl)ethyl]-3-pyridazinecarboxamide

Produkt 1

HCID 16035661HCID 16035661, Verbindung

Versuchsvorschrift

Following the procedure of Example 15, making variations only as required to use 6-chloropyridazine-3-carboxylic acid [2-(4-metoxyphenyl)ethyl]amide in place of 6-chloropyridazine-3-carboxylic acid (2-cyclopropyl-2-hydroxyethyl)amide to react with piperazin-1-yl-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (12% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.93, 7.74, 7.63, 7.56, 7.36, 7.12, 6.92, 6.81, 4.08-3.46, 3.33, 2.87.

Quellen und Nachweise

ORD-Eintrag
ord-86c0c47154ea4eba9840a74c40f49de9
Quelldatensatz
uspto-grants-2008_02
Patentnummer
US07335658B2

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