反应详情

To a stirred solution of 1-{2-[(2R)-4-(6-fluoro-1-naphthyl)-2-methyl-piperazinyl]ethyl}-3,4-dihydro-1H-2-benzopyran-6-carbonitrile (0.50 g, 1.2 mmol) in dry THF (4 mL) was added lithium aluminium hydride (1M solution in THF) (1.4 mL, 1.4 mmol) and the mixture stirred overnight at room temperature. The reaction was quenched by cautious addition of 2M sodium hydroxide, then extracted into chloroform. The combined organic extracts were dried (MgSO4), filtered and evaporated in vacuo. The crude product was purified by preparative LC-MS to yield the title compound as a yellow oil. M+H=480.

1. customThe reaction was quenched by cautious addition of 2M sodium hydroxide
2. extractionextracted into chloroform
3. dry with materialThe combined organic extracts were dried (MgSO4)
4. filtrationfiltered
5. customevaporated in vacuo
6. customThe crude product was purified by preparative LC-MS