反应详情

To 1.7 g (4.7 mmol) trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester in 22 ml DMA, 1.34 ml (14 mmol, 3 eq) N-allylmethylamine were added over a period of 10 min. The reaction was stirred at RT over night, concentrated and the residue was dissolved in CH2Cl2/5% aqueous NaHCO3. The phases were separated and the inorganic phase was extracted with CH2Cl2, the combined organic phases were washed with brine, dried over Na2SO4 and concentrated to yield 1.5 g (92%) trans-(4-[4-(Allyl-methyl-amino)-butoxy]-cyclohexyl)-methyl-carbamic acid tert-butyl ester as colorless oil, MS: 355 (MH+).

1. concentrationconcentrated
2. dissolutionthe residue was dissolved in CH2Cl2/5% aqueous NaHCO3
3. customThe phases were separated
4. extractionthe inorganic phase was extracted with CH2Cl2
5. washthe combined organic phases were washed with brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated