反应详情

A mixture of 3.51 g of 5,11-dihydro-11-[3-(1-piperazinyl)-propionyl]-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one and 1.6 g of sodium carbonate were added to the mixture of 2.14 g of benzylbromide in 100 ml of absolute ethanol and the mixture was refluxed for 6 hours. Then, the hot mixture was vacuum filtered and the filtrate was evaporated to dryness in vacuo and purified by a silica gel column. The residue of the eluent was then crystallized from xylene to obtain a 42% yield of 11-[3-(4-benzyl-1-piperazinyl)-propionyl]-5,11-dihydro-6H-pyrido-[2,3-b][1,4]-benzodiazepine-6-one melting at 205°-207° C.

1. temperaturethe mixture was refluxed for 6 hours
2. filtrationfiltered
3. customthe filtrate was evaporated to dryness in vacuo
4. custompurified by a silica gel column
5. customThe residue of the eluent was then crystallized from xylene