反应详情

The procedure of Example 1 was employed utilizing N-benzylaniline and cyclopentyl phosphonic dichloride. The crude product produced as a result of the chromatographic separation was slurried in methylcyclohexane and further purified on a chromatographic system employing an alumina column using chloroform (containing 0.75% ethyl alcohol) as the eluant. Fractions containing the benzazaphosphole were crystallized using benzene and methylcyclohexane to yield 1-cyclopentyl-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide as a yellow solid. A second crop was obtained to give a total yield of 0.85 g (5% yield) of 1-cyclopentyl-2-phenyl-2,3-dihydro-1H-2,1-benzazaphosphole-1-oxide having a melting point of 123°-125° C. and the following analysis:

1. customThe crude product produced as
2. customa result of the chromatographic separation
3. customfurther purified on a chromatographic system
4. additionFractions containing the benzazaphosphole
5. customwere crystallized