Hydrochloric Acid → (3S*,4R*)-3-(aminomethyl)-1-azabicyclo[2.2.1]heptan-3-ol dihydrochloride

(3R,4R)-3-Hydroxy-1-azabicyclo[2.2.1]heptane-3-carbonitrile (390 mg, 2.82 mmol) was dissolved in THF (1 mL). Borane-THF complex was added (2.9 ml, 2.90 mmol) and the mixture was allowed to stir for 20 min, at which time an additional portion of Borane-THF complex (5.7 ml, 5.70 mmol) was added and the mixture brought to reflux for 3 h. The reaction mixture was cooled to ambient temperature and carefully quenched with 5 ml EtOH followed by 0.5 ml water and allowed to stir overnight. The mixture was evaporated to dryness and azeotroped with EtOH, re-dissolved in acetone (10 mL) and to this was carefully added 3N HCl (10 mL, 30 mmol). The effervescent reaction was allowed to stir for 2 hours, at which time bubbling had ceased and the reaction was evaporated to near-dryness and azeotroped several times with EtOH, at which point the product began to crystallize from solution. After ˜5 cycles of azeotroping, the residue was suspended in EtOH and solids were collected by filtration to afford (3S,4R)-3-(aminomethyl)-1-azabicyclo[2.2.1]heptan-3-ol dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.02 (br. s., 1H) 8.27 (br. s., 3H) 6.29 (s, 1H) 2.86-3.63 (m, 9H) 2.14-2.37 (m, 1H) 1.64-2.05 (m, 1H). Optical rotation (4.01 mg/mL, water)=−15.01°.

1. additionBorane-THF complex was added (2.9 ml, 2.90 mmol)
2. additionwas added
3. temperatureto reflux for 3 h
4. customcarefully quenched with 5 ml EtOH
5. stirringto stir overnight
6. customThe mixture was evaporated to dryness
7. customazeotroped with EtOH
8. dissolutionre-dissolved in acetone (10 mL)
9. customThe effervescent reaction
10. stirringto stir for 2 hours, at which time
11. custombubbling
12. customthe reaction was evaporated to near-dryness
13. customazeotroped several times with EtOH
14. customto crystallize from solution
15. customAfter ˜5 cycles of azeotroping
16. filtrationsolids were collected by filtration

ORD record

ord-1cc0bdd8037045a2bc77fdce759c5fb9

Source dataset

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08278320B2