反应详情

4-((4-Chlorophenoxy)methyl)-2-(methylsulfonyl)pyrimidine Part B (0.8 g, 2.68 mmol) was stirred in 1N NaOH (5 mL, 5.36 mmol) and THF (13 mL) at 80° C. for 30 min. The solution was cooled to RT, acidified to pH 3 using 10% aqueous HCl. The precipitated product after isolation by filtration, was washed with CH2Cl2 to afford the desired product 4-((4-chlorophenoxy)methyl)pyrimidin-2(1H)-one 6C (0.344 g, 1.45 mmol, 54% yield) as a light brown solid. 1H NMR (400 MHz, DMSO-d6) δ 7.93 (1H, d, J=5.27 Hz), 7.28-7.36 (2H, m), 6.94-7.02 (2H, m), 6.10 (1H, d, J=5.27 Hz), 4.78 (2H, s).

1. filtrationThe precipitated product after isolation by filtration
2. washwas washed with CH2Cl2