1-({[(1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentyl]carbonyl}oxy)ethyl 2-ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate → HCID 178467376, compound

HRID 2067146Notes

Reaction equation

HRID 2067146 reaction equation
[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[N:26](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:25]=[N:24][N:23]=3)=[CH:12][CH:11]=2)[C:7]2[C:46]([C:50]([O:52][CH:53]([O:55][C:56]([C@H:58]3[CH2:62][C@H:61]([O:63][N+:64]([O-:66])=[O:65])[C@@H:60]([O:67][CH3:68])[CH2:59]3)=[O:57])[CH3:54])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2]>CO>[CH2:1]([O:3][C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:22]3[NH:23][N:24]=[N:25][N:26]=3)=[CH:14][CH:15]=2)[C:7]2[C:46]([C:50]([O:52][CH:53]([O:55][C:56]([C@H:58]3[CH2:62][C@H:61]([O:63][N+:64]([O-:66])=[O:65])[C@@H:60]([O:67][CH3:68])[CH2:59]3)=[O:57])[CH3:54])=[O:51])=[CH:47][CH:48]=[CH:49][C:6]=2[N:5]=1)[CH3:2]

Participants

3

Reactant 1

HCID 866423841-({[(1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentyl]carbonyl}oxy)ethyl 2-ethoxy-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate

Product 1

HCID 178467376HCID 178467376, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A methanol (20 mL) solution of 1-({[(1R,3S,4S)-3-methoxy-4-(nitrooxy)cyclopentyl]carbonyl}oxy)ethyl 2-ethoxy-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate (1420 mg, 1.62 mmol) was heated to 70° C. for 2 hours. The reaction mixture was concentrated in vacuo, and the residue was purified by column chromatography, eluting with 0/100→10/90 methanol/dichloromethane to give the title compound as a white solid. Chromatography of the diasteromeric mixture over Chiralpak IC column, eluting with methanol/carbon dioxide, afforded the separate disastereomers D1 and D2.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was purified by column chromatography
  3. washeluting with 0/100→10/90 methanol/dichloromethane

Sources & evidence

ORD record
ord-d13dfd0c4d7d427aa9c9f025bd3a573d
Source dataset
uspto-grants-2012_10
Patent number
US08293777B2

Reaction notes

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