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The reaction was carried out similarly as described in the preparation of compound 112, using compound 111 (0.08 mmol) and 2-amino-2-methyl-1-propanol (0.08 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 100:0 as the eluent to afford the title compound as almost yellow solid. 13C NMR (DMSOd6) δ 8.74 (s, 1H), 8.50 (s, 1H), 7.90 (dd, 1H), 7.85 (bs, 1H), 7.75 (d, 1H), 7.50-7.33 (m, 4H), 7.11 (m, 1H), 6.83 (m, 1H), 6.78 (m, 1H), 5.07 (s, 2H), 4.80 (t, 1H), 3.40 (d, 2H), 2.33 (s, 3H), 1.21 (s, 6H)

1. customThe crude product was purified by continuous gradient flash chromatography