反应详情

Following the procedure as described in Example 14, making variations as required to replace ethyl 3-methyl-5-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiophene-2-carboxylate with ethyl 5-(3-(cyclopropylmethyl)-2-oxoimidazolidin-1-yl)-3-methylthiophene-2-carboxylate, the title compound was obtained as a colorless solid in 80% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.32 (br s, 1H), 6.27 (s, 1H), 3.89-3.78 (m, 2H), 3.69-3.58 (m, 2H), 3.06 (d, J=6.9 Hz, 2H), 2.39 (s, 3H), 1.00-0.86 (m, 1H), 0.53-0.44 (m, 2H), 0.25-0.18 (m, 2H); MS (ES+) m/z 281.2 (M+1).