反应详情

温度

20 °C

0.073 g (1.819 mmol) of 2-molar aqueous sodium hydroxide solution was added to 0.165 g (0.455 mmol) of methyl[3-methyl-5-phenyl-1-(pyrazin-2-yl)-1H-pyrazol-4-yl]acetate (see A3) dissolved in 5 ml of methanol, and the mixture was stirred at 20° C. for 1 h. The methanol was removed under reduced pressure and the residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane. The aqueous phase was extracted with 15 ml of dichloromethane, acidified with concentrated hydrochloric acid (pH=3) and extracted three times with in each case 15 ml of dichloromethane. Drying of the combined organic phases and removal of the solvent under reduced pressure gave 0.080 g (59.7% of theory) of a colorless foamy solid, melting point 125° C.

1. customThe methanol was removed under reduced pressure
2. additionthe residue was poured into a mixture of 10 ml of water and 15 ml of dichloromethane
3. extractionThe aqueous phase was extracted with 15 ml of dichloromethane
4. extractionextracted three times with in each case 15 ml of dichloromethane
5. customDrying of the combined organic phases and removal of the solvent under reduced pressure
6. customgave 0.080 g (59.7% of theory) of a colorless foamy solid, melting point 125° C.