反应详情

1.00 g of 5-[4-(4-methoxymethyl-phenyl)-imidazol-1-yl]-2-nitro-4-trifluoromethyl-benzoic acid methyl ester in 20 ml of tetrahydrofuran is hydrogenated in presence of 200 mg of platinum on carbon. After filtration of the catalyst the solution is evaporated to dryness yielding 0.661 g of 2-hydroxyamino-5-[4-(4-methoxymethyl-phenyl)-imidazol-1-yl]-4-trifluoromethyl-benzoic acid methyl ester as a yellow solid. 1H-NMR (DMSO-d6, 400 MHz): 3.30 s, 3H; 3.82 s, 3H; 4.40 s, 2H; 7.35 d, J=10.4 Hz, 2H; 7.62 s, 1H; 7.80 d, J=10.4 Hz, 2H; 7.85-7.90 m, 3H.

1. filtrationAfter filtration of the catalyst the solution
2. customis evaporated to dryness