反应详情

温度

50 °C

tert-Butyl (2R)-4-methyl-1-oxo-1-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino]pentan-2-ylcarbamate (588 mg) was dissolved in ethanol (2.9 mL), and concentrated hydrochloric acid (1.2 mL) was added thereto. The mixture was heated at 50° C. while being stirred for 30 minutes. The resultant mixture was neutralized with saturated sodium bicarbonate solution under cooling on ice. Subsequently, the mixture was extracted with ethyl acetate, and the aqueous layer was further extracted with ethyl acetate. The organic layers were combined, and the combined organic layer was washed with saturated sodium chloride solution, followed by drying over sodium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (416 mg) was yielded.

1. temperatureunder cooling on ice
2. extractionSubsequently, the mixture was extracted with ethyl acetate
3. extractionthe aqueous layer was further extracted with ethyl acetate
4. washthe combined organic layer was washed with saturated sodium chloride solution
5. dry with materialby drying over sodium sulfate
6. customThe solvent was evaporated under reduced pressure, whereby the title compound (416 mg)
7. customwas yielded