反应详情

温度

70 °C

tert-Butyl 2-methyl-1-[(2R)-4-methyl-1-oxo-1-[2-oxo-8-(2-oxopyrrolidin-1-yl)-1-(thiophen-3-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-ylamino]pentan-2-ylamino]-1-oxopropan-2-ylcarbamate (2.8 g) was dissolved in ethanol (28 mL), and concentrated hydrochloric acid (7.5 mL) was added thereto. The mixture was heated at 70° C. while being stirred for 30 minutes, and then neutralized with saturated aqueous sodium bicarbonate solution under cooling on ice. Subsequently, the resultant mixture was extracted with chloroform and water, and the aqueous layer was further extracted with chloroform. The organic layers were combined. The combined organic layer was washed with saturated aqueous sodium chloride solution, and then dried over sodium sulfate. The solvent was evaporated under reduced pressure, whereby the title compound (2.30 g) was yielded.

1. temperatureunder cooling on ice
2. extractionSubsequently, the resultant mixture was extracted with chloroform and water
3. extractionthe aqueous layer was further extracted with chloroform
4. washThe combined organic layer was washed with saturated aqueous sodium chloride solution
5. dry with materialdried over sodium sulfate
6. customThe solvent was evaporated under reduced pressure, whereby the title compound (2.30 g)
7. customwas yielded