Methanol → HCID 53779320, 화합물

HRID 2071080노트

반응식

HRID 2071080 반응식
[C:1]([C:5]1[CH:6]=[N:7][CH:8]=[C:9]([CH2:11][O:12][Si](C(C)C)(C(C)C)C(C)C)[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].CO>Cl>[C:1]([C:5]1[CH:10]=[C:9]([CH2:11][OH:12])[CH:8]=[N:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 2

HCID 887MethanolHCID 686715593-Tert-butyl-5-((triisopropylsilyloxy)methyl)pyridine

생성물 1

HCID 53779320HCID 53779320, 화합물수율 45.9%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

3-tert-butyl-5-((triisopropylsilyloxy)methyl)pyridine (0.7 g, 2.637 mmol) was dissolved in HCl in methanol (42 mL, 1.25M, 52.73 mmol) at room temperature and stirred for overnight. The solvent was removed under vacuum, dissolved in chloroform and washed with saturated aqueous Na2CO3. The resulting organic solvent was dried, concentrated to give a residue which was purified by flash column chromatography to give pure (5-tert-butylpyridin-3-yl)methanol (0.2 g). 1H NMR (CDCl3): d: 1.280 (s, 9H), 4.663 (s, 2H), 7.730 (s, 1H), 8.225 (s, 1H), 8.368 (s, 1H).

후처리

  1. customThe solvent was removed under vacuum
  2. dissolutiondissolved in chloroform
  3. washwashed with saturated aqueous Na2CO3
  4. customThe resulting organic solvent was dried
  5. concentrationconcentrated
  6. customto give a residue which
  7. customwas purified by flash column chromatography

출처 및 근거

ORD 기록
ord-353f117769a8442895501abf0f93dcbe
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08299267B2

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