反应详情

To a solution of (5.23 mmol) of 3-(quinolin-2-yl)methyloxyphenol and (5.23 mmol) of the bromide from step B in 90 ml of 8:1--acetone:DMF is added 1.52 g (10.97 mmol, 2.1 equiv) of K2CO3. The mixture is refluxed overnight, then partitioned between EtOAc and H2O. The organics are dried, filtered, and concentrated in vacuo. This is then purified by flash column chromatography to give ethyl 2-(2-(3-((quinolin-2-yl)methyloxy)phenoxymethyl)phenoxy)propionate which is used directly in the next step.

1. temperatureThe mixture is refluxed overnight
2. custompartitioned between EtOAc and H2O
3. customThe organics are dried
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThis is then purified by flash column chromatography