Hydrochloric Acid → N-Boc-Tyr(Bn)-Ala-Trp-OMe

HRID 2074363Notes

Reaction equation

HRID 2074363 reaction equation
Cl.[NH2:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.[NH:18]([C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C@H:19]([C:35]([NH:37][C@H:38]([C:40](O)=[O:41])[CH3:39])=[O:36])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:23][CH:22]=1.C1CCC(N=C=NC2CCCCC2)CC1.C1C=CC2N(O)N=NC=2C=1>C1COCC1>[NH:18]([C:43]([O:45][C:46]([CH3:47])([CH3:49])[CH3:48])=[O:44])[C@H:19]([C:35]([NH:37][C@H:38]([C:40]([NH:2][C@H:3]([C:14]([O:16][CH3:17])=[O:15])[CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1)=[O:41])[CH3:39])=[O:36])[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:23][CH:22]=1

Participants

7

Reactant 5

HCID 313Hydrochloric AcidHCID 10868DicyclohexylcarbodiimideHCID 757711-HydroxybenzotriazoleHCID 77980L-Tryptophan, methyl esterHCID 57611766N-Boc-Tyr(Bn)-Ala-OH

Product 1

HCID 44424692N-Boc-Tyr(Bn)-Ala-Trp-OMeYield 56.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

compound NR36. Same procedure as above with HCl, Trp-OCH3 (255 mg, 1 mmol), N-Boc-Tyr(Bn)-Ala-OH (444 mg, 1 mmol), DCC (259 mg, 1.26 mmol) and HOBt (172 mg, 1.27 mmol) in THF (15 mL). The crude residue was chromatographed over silica gel to afford a white solid (361 mg, 56%). 1H NMR (300 MHz, DMSO-d6) δ 1.22 (d, J=7 Hz, 3H, CH3), 1.29 (s, 9H, (CH3)3), 2.62 and 2.92 (ABX system, 2H, CH2P), 3.08 and 3.13 (ABX system, 2H, CH2β) 3.55 (s, 3H, OCH3), 4.10 (m, 1H, CHα), 4.36 (m, 1H, CHα), 4.49 (m, 1H, CHα), 5.03 (s, 2H, CH2 (OBn)), 6.85-7.50 (m, 15H, 14 aromatic H+1 NH), 7.97 (d, J=7.3 Hz, 1H), 8.34 (d, J=7.0 Hz, 1H), 10.88 (s, 1NH). 13C NMR (75 MHz, DMSO-d6) δ 18.2 (CH3), 26.8 (CH2 Trp), 28.0 ((CH3)3), 36.3 (CH2 Tyr), 47.6, 51.6, 53.0, 55.6 (CHα Ala, Tyr, Trp or OCH3), 69 (CH2 (OBn)), 77.9 (C(CH3)3), 109.0 (aromatic C), 111.2, 114.2, 117.8, 118.3, 120.8, 123.6 (aromatic CH), 126.9 (aromatic C), 127.4, 127.6, 128.2, 130.0 (aromatic CH), 130.2, 135.9, 137.1 (aromatic C), 155.1, 156.7 (Car-O or CO carbamate), 171.2, 171.9, 172.1 (2 CO amide or CO ester). Anal. Calcd. for C36H42N4O7, 0.5H2O: C, 66.34; H, 6.65; N, 8.60. Found: C, 66.29; H, 6.64; N, 8.48.

Workup

  1. customThe crude residue was chromatographed over silica gel

Sources & evidence

ORD record
ord-6c8fbeff64a140e8b81693e0424dcca7
Source dataset
uspto-grants-2011_04
Patent number
US07919468B2

Reaction notes

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