Methyl (2-ethyl-4'-hydroxy-1,1'-biphenyl-4-yl)acetate → Methyl (2-ethyl-4'-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1'-biphenyl-4-yl)acetate
Reaction equation
[CH2:1]([C:3]1[CH:8]=[C:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[CH3:2].CS(O[CH2:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[C:29]([O:37]COC)[C:28]=1[CH:41](OC)[O:42]C)(=O)=O>>[CH2:1]([C:3]1[CH:8]=[C:7]([CH2:9][C:10]([O:12][CH3:13])=[O:11])[CH:6]=[CH:5][C:4]=1[C:14]1[CH:15]=[CH:16][C:17]([O:20][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]([F:35])([F:36])[F:34])=[C:29]([OH:37])[C:28]=2[CH:41]=[O:42])=[CH:18][CH:19]=1)[CH3:2]Participants
3
Procedure
According to a method similar to Example (40-2) and Example (8-3), from methyl (2-ethyl-4′-hydroxy-1,1′-biphenyl-4-yl)acetate (4.90 g, 18.1 mmol) obtained in Example (26-4) and 2-(dimethoxymethyl)-3-(methoxymethoxy)-4-(trifluoromethyl)benzyl methanesulfonate (8.35 g, 21.5 mmol) obtained in Example (26-5), methyl (2-ethyl-4′-{[2-formyl-3-hydroxy-4-(trifluoromethyl)benzyl]oxy}-1,1′-biphenyl-4-yl)acetate was obtained as a colorless solid (6.77 g, two-step total yield: 79%).
Sources & evidence
- ORD record
- ord-e28fd3303a564d379a1dc7a220a76786
- Source dataset
- uspto-grants-2011_04
- Patent number
- US07923573B2
Reaction notes
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