反应详情

温度

40 °C

A mixture of 2-(4-{[5-chloro-2-{[4-(4-pyridinyl)butanoyl]amino}-4-(trifluoromethyl)phenyl]amino}phenyl)ethyl acetate (step 3, 220 mg, 0.42 mmol) and 2N NaOH (15 ml) in ethanol (20 ml) was stirred at 40° C. for 7 h. The solvent was removed and the residue was added water (50 ml). The mixture was extracted with ethyl acetate (100 ml). The organic layer was washed with brine (50 ml), then dried (Na2SO4). After removal of solvent, the crude product was purified by flash column chromatography eluting with dichloromethane:methanol (20:1) to afford 105 mg (54%) of the title compound as pale brown oil.

1. customThe solvent was removed
2. additionthe residue was added water (50 ml)
3. extractionThe mixture was extracted with ethyl acetate (100 ml)
4. washThe organic layer was washed with brine (50 ml)
5. dry with materialdried (Na2SO4)
6. customAfter removal of solvent
7. customthe crude product was purified by flash column chromatography
8. washeluting with dichloromethane:methanol (20:1)