反应详情

A mixture of 654 mg of 4,6-dichloro-2-(4-pyridyl)-5-(p-tolyl)-pyrimidine and 1051 mg of 5-isopropyl-2-pyridine sulfonamide potassium salt (Example 1e) in 20 ml of DMF was stirred for 16 h at room temperature. Eventually, the solvent was distilled off under reduced pressure and the resulting residue was treated with 100 ml of 10% aqueous acetic acid and 100 ml of DCM. The layers were separated. The aqueous layer was extracted two more times with DCM. The combined organic layers were washed once with water, dried over MgSO4 and evaporated. The remaining residue was crystallised from isopropanol:diethyl ether. The yellow crystals were collected, washed with cold isopropanol and diethyl ether, and dried under high vacuum to furnish 870 mg of 5-isopropyl-N-[6-chloro-5-(p-tolyl)-2-(4-pyridyl)4-pyrimidinyl]-2-pyridine sulfonamide. LC-MS: tR=5.06 min, [M+1]+=480.40, [M−1]−=478.48.

1. distillationEventually, the solvent was distilled off under reduced pressure
2. additionthe resulting residue was treated with 100 ml of 10% aqueous acetic acid and 100 ml of DCM
3. customThe layers were separated
4. extractionThe aqueous layer was extracted two more times with DCM
5. washThe combined organic layers were washed once with water
6. dry with materialdried over MgSO4
7. customevaporated
8. customThe remaining residue was crystallised from isopropanol
9. customThe yellow crystals were collected
10. washwashed with cold isopropanol and diethyl ether
11. customdried under high vacuum