反应详情

温度

90 °C

A suspension of 400 mg of 4-tert.-butyl-N-[6-(4-hydroxy-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-benzene sulfonamide (Example 2c), 116 mg of 4,6-dimethoxy-2-methyl-sulfonylpyrimidine and 147 mg of potassium carbonate in 15 ml of DMF was stirred at 90° C. for 16 h. Further 42 mg of 4,6-dimethoxy-2-methyl-sulfonylpyrimidine was added and stirring was continued at 90° C. for 24 h. Eventually, the solvent was removed in vacuo, and the resulting residue partitioned between 50 ml of 5% aqueous acetic acid and 50 ml of DCM. The organic layer was separated and the aqueous layer was extracted two more times with 50 ml of DCM. The combined organic layers were washed with water, dried over MgSO4 and evaporated. The remaining oil was purified by column chromatography on silica gel eluting with toluene: ethyl acetate 4:1 to 1:1. The product obtained was recrystallised from ethyl acetate:diethyl ether to give 76 mg of 4-tert.-butyl-N-[6-(4-(4,6-dimethoxy-2-pyrimidinyloxy)-2-butynyloxy)-5-(o-methoxyphenoxy)-2-(4-pyridyl)-4-pyrimidinyl]-benzene sulfonamide as white crystals. LC-MS: tR=5.84 min, [M+1]+=713.35, [M−1]−=711.45.

1. stirringstirring
2. waitwas continued at 90° C. for 24 h
3. customEventually, the solvent was removed in vacuo
4. customthe resulting residue partitioned between 50 ml of 5% aqueous acetic acid and 50 ml of DCM
5. customThe organic layer was separated
6. extractionthe aqueous layer was extracted two more times with 50 ml of DCM
7. washThe combined organic layers were washed with water
8. dry with materialdried over MgSO4
9. customevaporated
10. customThe remaining oil was purified by column chromatography on silica gel eluting with toluene: ethyl acetate 4:1 to 1:1
11. customThe product obtained
12. customwas recrystallised from ethyl acetate