反应详情

The title compound was prepared in a manner analogous to Step 3 of Method A, from 4-[4-amino-5-(2,6-difluoro-benzoyl)-thiazol-2-ylamino]-benzoic acid (3) and 2,N1,N1-trimethyl-propane-1,2-diamine (Tsuji, et al Chem. Pharm. Bull. Vol. 12, pp. 946-950 (1964)). Radial chromatography with 0.5% (58% NH4OH)/5%MeOH/CHCl3 gave a yellow oil, which was placed in CHCl3, treated with 4M HCl in dioxane (2.2 equiv), and azeotroped from CHCl3 in succession to provide 100 mg of yellow powder in 23% yield, mp 275-290° C. (decomp).