18-Crown-6 → 4-(2,6-Dimethyl-4-nitrophenoxy)-2-(4-fluorobenzenesulfonyl)phenol

HRID 2086165Notes

Reaction equation

HRID 2086165 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[C:15]([OH:17])[CH:14]=[CH:13][C:12]=2[OH:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1.C[Si]([N-][Si](C)(C)C)(C)C.[K+].C1OCCOCCOCCOCCOCCOC1.Cl[C:48]1[C:53]([CH3:54])=[CH:52][C:51]([N+:55]([O-:57])=[O:56])=[CH:50][C:49]=1[CH3:58]>CN1CCCC1=O>[CH3:54][C:53]1[CH:52]=[C:51]([N+:55]([O-:57])=[O:56])[CH:50]=[C:49]([CH3:58])[C:48]=1[O:17][C:15]1[CH:14]=[CH:13][C:12]([OH:18])=[C:11]([S:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)(=[O:10])=[O:9])[CH:16]=1

Participants

6

Reactant 4

HCID 2855718-Crown-6HCID 3251421Potassium bis(trimethylsilyl)amideHCID 99205692-Chloro-1,3-dimethyl-5-nitrobenzeneHCID 223448682-(4-Fluorobenzenesulfonyl)benzene-1,4-diol

Product 1

HCID 223448994-(2,6-Dimethyl-4-nitrophenoxy)-2-(4-fluorobenzenesulfonyl)phenolYield 73.8%

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 2-(4-Fluoro-benzenesulfonyl)-benzene-1,4-diol (10.0 grams, 37 mmol) in dry 1-methyl-2-pyrrolidinone (100 mL) with 3° A molecular sieves (3.0 grams) was sparged with dry nitrogen for 15 minutes at room temperature. The solution was cooled to 0° C. and potassium bis(trimethylsilyl)amide (18.6 grams, 93.2 mmol) was added in a single portion to give a deep red suspension. The suspension was warmed to room temperature with continued sparging. 18-Crown-6 (10.8 grams 41.0 mmol) was added in a single portion and the resulting solution was cooled to 0° C. To the cooled suspension was added 2-chloro-1,3-dimethyl-5-nitro-benzene (8.30 grams, 44.7 mmol) to give a brown solution and sparging was ceased. The solution was allowed to warm to room temperature and stirred under dry nitrogen for 3 hours. The reaction mixture was poured into 1M hydrochloric acid (1 L) at 0° C. and extracted with ethyl acetate (3 times 300 ml). The combined organic extracts were washed with 1 M hydrochloric acid (4 times 1 L), brine (1 L), dried over anhydrous sodium sulfate and filtered. The filtrate was treated with activated carbon, filtered, and concentrated. The crude product was purified by chromatography on silica gel (150 grams) (methanol:hexanes:methylene chloride=1:9:10, 1.5 L) to give the title compound as a tan solid (11.4 grams). 1H NMR (400 MHz, CD3OD) δ8.05 (s, 1H), 8.00-7.95 (m, 2H), 7.28 (d, 1H), 7.26-7.20 (m, 2H), 6.93 (dd, 1H), 6.82 (d, 1H), 2.19 (s, 6H). MS (APCI−) Calc.: 417.1, Found: 416.0 (M−1).

Workup

  1. customto give a deep red suspension
  2. temperatureThe suspension was warmed to room temperature with continued sparging
  3. temperaturethe resulting solution was cooled to 0° C
  4. customto give a brown solution
  5. customsparging
  6. temperatureto warm to room temperature
  7. additionThe reaction mixture was poured into 1M hydrochloric acid (1 L) at 0° C.
  8. extractionextracted with ethyl acetate (3 times 300 ml)
  9. washThe combined organic extracts were washed with 1 M hydrochloric acid (4 times 1 L), brine (1 L)
  10. dry with materialdried over anhydrous sodium sulfate
  11. filtrationfiltered
  12. additionThe filtrate was treated with activated carbon
  13. filtrationfiltered
  14. concentrationconcentrated
  15. customThe crude product was purified by chromatography on silica gel (150 grams) (methanol:hexanes:methylene chloride=1:9:10, 1.5 L)

Sources & evidence

ORD record
ord-d27618c0904b4be883d35c4acce313b3
Source dataset
uspto-grants-2004_04
Patent number
US06723744B2

Reaction notes

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