反应详情

温度

35 °C

Into 6 mL of tetrahydrofuran were dissolved 6.4 mg of RuCl[(1R,2R)-p-TsNHCH(C6H5)CH(C6H5)NH2] (p-cymene), 5 mL of a mixture of formic acid-triethylamine (5:2 in molar ratio), 1.0 g of isopropyl 4,4,4-trifluoro-3-oxobutanoate, and the whole was stirred at 35° C. for 15 hours, followed by concentration under reduced pressure using an evaporator. To the resulting concentrate were added 10 mL of water and 10 mL of ethyl acetate, and then a saturated sodium carbonate aqueous solution was added thereto under stirring until the pH became 7 or higher. The ethyl acetate layer separated from the aqueous layer was concentrated to obtain optically active isopropyl 4,4,4-trifluoro-3-hydroxybutanoate. Upon the measurement under the above conditions, the optical purity and conversion were found to be 96.2% e.e. and 100%, respectively.

1. concentrationfollowed by concentration under reduced pressure
2. customan evaporator
3. concentrationTo the resulting concentrate
4. additionwere added 10 mL of water and 10 mL of ethyl acetate
5. additiona saturated sodium carbonate aqueous solution was added
6. stirringunder stirring until the pH
7. customThe ethyl acetate layer separated from the aqueous layer
8. concentrationwas concentrated