反应详情

温度

65 °C

A 2 L 3-neck round-bottom flask equipped with an air condenser and a magnetic stirrer was charged with N,N-dimethyldodecylamine (297.24 g), 1-bromo-3-chloropropane (220.44 g) and methanol (250 mL). The reaction was maintained at 65° C. for 24 hours. Methanol was removed by rotary evaporation under reduced pressure to yield a brown sludge. To the sludge was added methyl-tert-butylether (2 liters) causing a white solid to form. The mixture was stirred for two hours and a semi-crystalline, white particulate was collected by vacuum filtration. The particulate was dried in a vacuum oven at 35° C. for 24 hours. Yield 228.2 grams (0.61 moles, 44%). (4-Chlorobutyl)dodecyldimethylammonium bromide and (6-chlorohexyl)dodecyldimethylammonium bromide can be prepared by a similar process using the appropriate bromochloroalkane and dodecyldimethylamine.

1. customA 2 L 3-neck round-bottom flask equipped with an air condenser and a magnetic stirrer
2. customMethanol was removed by rotary evaporation under reduced pressure
3. customto yield a brown sludge
4. customto form
5. filtrationa semi-crystalline, white particulate was collected by vacuum filtration
6. customThe particulate was dried in a vacuum oven at 35° C. for 24 hours
7. custom(4-Chlorobutyl)dodecyldimethylammonium bromide and (6-chlorohexyl)dodecyldimethylammonium bromide can be prepared by a similar process