反应详情

A mixture of (1R*,12R*,5S*,6R*)-8-benzyl-2-{[3,5-bis(trifluoromethyl)phenyl]methoxy}-6-[4-methyloxazol-2-yl]-1-phenyl-8-azabicyclo[3.2.1]octane (Example 76; 53 mg, 0.09 mmol), 10% palladium on charcoal (135 mg) ethanol (10 ml) was stirred under hydrogen atmosphere (1 atm) at +65° C. for 30 minutes. The reaction mixture was cooled to room temperature, flushed with nitrogen gas and filtered through a pad of Celite™. The filtrate was concentrated and purified by preparative TLC (dichloromethane:methanol) to give the title compound (38 mg, 84%). The hydrochloride salt of the title compound was prepared by treatment with ethereal HCl.

1. customflushed with nitrogen gas
2. filtrationfiltered through a pad of Celite™
3. concentrationThe filtrate was concentrated
4. custompurified by preparative TLC (dichloromethane:methanol)