反应详情

Followed the procedure as described in EXAMPLE 1, starting with tert-butyl 1-(3-aminopyridin-4-yl)piperidin-3-ylcarbamate and 2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)-5-(tert-butoxycarbonylamino)thiazole-4-carboxylic acid. Obtained the desired product as a white solid (13.5 mg, 32%). 1H NMR (500 MHz, DMSO) δ 9.38 (s, 1H), 8.18 (d, J=5.2 Hz, 1H), 7.26 (s, 2H), 7.09 (d, J=5.2 Hz, 1H), 3.08 (d, J=10.9 Hz, 2H), 2.96 (d, J=11.4 Hz, 4H), 2.62 (d, J=17.6 Hz, 1H), 2.43-2.36 (m, 1H), 2.15 (s, 1H), 1.82 (dd, J=63.4, 20.3 Hz, 4H), 1.18 (d, J=11.6 Hz, 2H). ESIMS m/z=388.2 (M+1).