反应详情

14 mg of 3-(2,6-dichlorophenyl)-7-(3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinolin]-6′-ylamino)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one was obtained as a white solid according to the same method as in Example 2, for which, however, tert-butyl 6′-amino-3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinoline]-2′-carboxylate obtained in the reaction of Production Example 19-5) was used in place of 2,4,4-trimethyl-1,2,3,4-tetrahydroisoquinolin-7-amine in Example 2, and 7-chloro-3-(2,6-dichlorophenyl)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one obtained in Production Example 7 was used in place of 7-chloro-3-(2,6-dichlorophenyl)-4-imino-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one. In addition, as a by-product, 30 mg of 3-(2,6-dichlorophenyl)-7-[(1-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)amino]-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one was obtained as a white solid. 3-(2,6-Dichlorophenyl)-7-(3′,4′-dihydro-2′H-spiro[cyclopropane-1,1′-isoquinolin]-6′-ylamino)-4-imino-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one:

1. customobtained in Production Example 7