反应详情

To a mixture of methyl 4-{[3-methyl-1-(3-methyl-1-benzofuran-2-yl)butyl]amino}benzoate (1.38 g) synthesized above, tetrahydrofuran (20 mL) and ethanol (20 mL) was added 1N aqueous sodium hydroxide solution (20 mL), and the mixture was stirred with heating under reflux overnight. In addition, 1N aqueous sodium hydroxide solution (20 mL) was added, and the mixture was stirred with heating under reflux for 3 hr. The reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid (40 mL) was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was washed with diisopropyl ether to give the title object compound (1.06 g, 80%) as a white solid.

1. temperaturewith heating
2. temperatureunder reflux overnight
3. stirringthe mixture was stirred
4. temperaturewith heating
5. temperatureunder reflux for 3 hr
6. concentrationThe reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid (40 mL)
7. additionwas added to the residue
8. extractionthe mixture was extracted with ethyl acetate
9. washThe extract was washed with water and saturated brine
10. dry with materialdried over magnesium sulfate
11. concentrationconcentrated under reduced pressure
12. washThe residue was washed with diisopropyl ether