反应详情

To a mixture of ethyl 3-{[(4-{[cyclopentyl(3-methyl-1-benzothiophen-2-yl)methyl]amino}phenyl)carbonyl]amino}propanoate (331 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (2.00 mL), and the mixture was stirred at room temperature for 1.5 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (2.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (276 mg, 89%) as a white solid.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in water (10 mL)
3. addition1N hydrochloric acid (2.00 mL) was added at 0° C
4. filtrationThe resulting precipitate was collected by filtration